Keratin 14

KRT14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TNU
Identifiers
Aliases	KRT14, CK14, EBS3, EBS4, K14, NFJ, keratin 14, EBS1D, EBS1, EBS1B, EBS1A, EBS1C
External IDs	OMIM: 148066; MGI: 96688; HomoloGene: 110439; GeneCards: KRT14; OMA:KRT14 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,586,895 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,098,374 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; skin of arm; ; skin of thigh; ; nipple; ; vulva; ; human penis; ; skin of hip; ; hair follicle; ; skin of abdomen; ; body of tongue;
	Top expressed in
	skin of external ear; ; lip; ; molar; ; skin of abdomen; ; skin of back; ; esophagus; ; cervix; ; conjunctival fornix; ; cornea; ; umbilical cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton; protein binding; keratin filament binding; structural molecule activity;
Cellular component	cytoplasm; cytosol; keratin filament; extracellular exosome; intermediate filament; intracellular anatomical structure; nucleus; cell periphery; basal part of cell;
Biological process	response to ionizing radiation; hemidesmosome assembly; hair cycle; ageing; response to zinc ion; epithelial cell differentiation; intermediate filament bundle assembly; epidermis development; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3861
	16664
	ENSG00000186847
	ENSMUSG00000045545
	P02533
	Q61781
	NM_000526
	NM_016958; NM_001313956; NM_001313957
	NP_000517
	NP_001300885; NP_001300886; NP_058654
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin 14 is a member of the type I keratin family of intermediate filament proteins. Keratin 14 was the first type I keratin sequence determined.^[5] Keratin 14 is also known as cytokeratin-14 (CK-14) or keratin-14 (KRT14). In humans it is encoded by the KRT14 gene.^[6]^[7]^[8]

Keratin 14 is usually found as a heterodimer with type II keratin 5 and form the cytoskeleton of epithelial cells.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186847 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045545 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hanukoglu I, Fuchs E (November 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins". Cell. 31 (1): 243–52. doi:10.1016/0092-8674(82)90424-X. PMID 6186381. S2CID 35796315.
^ Coulombe PA, Hutton ME, Letai A, Hebert A, Paller AS, Fuchs E (September 1991). "Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses". Cell. 66 (6): 1301–11. doi:10.1016/0092-8674(91)90051-Y. PMID 1717157. S2CID 11965913.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ "Entrez Gene: KRT14 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186847 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045545 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6186381-5] Hanukoglu I, Fuchs E (November 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins". Cell. 31 (1): 243–52. doi:10.1016/0092-8674(82)90424-X. PMID 6186381. S2CID 35796315.

[pmid1717157-6] Coulombe PA, Hutton ME, Letai A, Hebert A, Paller AS, Fuchs E (September 1991). "Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses". Cell. 66 (6): 1301–11. doi:10.1016/0092-8674(91)90051-Y. PMID 1717157. S2CID 11965913.

[pmid16831889-7] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[entrez-8] "Entrez Gene: KRT14 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)".

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