| KRT5 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A, keratin 5, EBS2E, EBS2B, EBS2C, EBS1, EBS2A, EBS2F, EBS2D |
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| External IDs | OMIM: 148040; MGI: 96702; HomoloGene: 55461; GeneCards: KRT5; OMA:KRT5 - orthologs |
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| Gene location (Human) |
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| | Chr. | Chromosome 12 (human)[1] |
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| | Band | 12q13.13 | Start | 52,514,575 bp[1] |
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| End | 52,520,530 bp[1] |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 15 (mouse)[2] |
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| | Band | 15 F2|15 56.98 cM | Start | 101,615,505 bp[2] |
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| End | 101,621,333 bp[2] |
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| Gene ontology |
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| Molecular function | | | Cellular component | | | Biological process | | | Sources:Amigo / QuickGO |
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| Wikidata |
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Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene.[5][6][7] It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells.[8][9] This protein is involved in several diseases including epidermolysis bullosa simplex and breast and lung cancers.[9][10][11]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186081 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061527 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: KRT5 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)".
- ^ Lersch R, Fuchs E (Jan 1988). "Sequence and expression of a type II keratin, K5, in human epidermal cells". Molecular and Cellular Biology. 8 (1): 486–493. doi:10.1128/mcb.8.1.486. PMC 363157. PMID 2447486.
- ^ Eckert RL, Rorke EA (Jun 1988). "The sequence of the human epidermal 58-kD (#5) type II keratin reveals an absence of 5' upstream sequence conservation between coexpressed epidermal keratins". DNA. 7 (5). Mary Ann Liebert, Inc.: 337–345. doi:10.1089/dna.1.1988.7.337. PMID 2456903.
- ^ Chan YM, Yu QC, LeBlanc-Straceski J, Christiano A, Pulkkinen L, Kucherlapati RS, et al. (Apr 1994). "Mutations in the non-helical linker segment L1-2 of keratin 5 in patients with Weber-Cockayne epidermolysis bullosa simplex". Journal of Cell Science. 107 (4): 765–774. doi:10.1242/jcs.107.4.765. PMID 7520042.
- ^ a b Atkinson SD, McGilligan VE, Liao H, Szeverenyi I, Smith FJ, Moore CB, et al. (Oct 2011). "Development of allele-specific therapeutic siRNA for keratin 5 mutations in epidermolysis bullosa simplex". The Journal of Investigative Dermatology. 131 (10): 2079–2086. doi:10.1038/jid.2011.169. PMID 21716320.
- ^ Mulvihill MS, Kratz JR, Pham P, Jablons DM, He B (Feb 2013). "The role of stem cells in airway repair: implications for the origins of lung cancer". Chinese Journal of Cancer. 32 (2): 71–74. doi:10.5732/cjc.012.10097 (inactive 12 July 2025). PMC 3845611. PMID 23114089.
{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
- ^ van de Rijn M, Perou CM, Tibshirani R, Haas P, Kallioniemi O, Kononen J, et al. (Dec 2002). "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome". The American Journal of Pathology. 161 (6): 1991–1996. doi:10.1016/S0002-9440(10)64476-8. PMC 1850928. PMID 12466114.