Plasmin

PLG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B2I, 1BML, 1BUI, 1CEA, 1CEB, 1DDJ, 1HPJ, 1HPK, 1I5K, 1KI0, 1KRN, 1L4D, 1L4Z, 1PK4, 1PKR, 1PMK, 1QRZ, 1RJX, 2DOH, 2DOI, 2KNF, 2L0S, 2PK4, 3UIR, 4A5T, 4CIK, 4DCB, 4DUR, 4DUU, 5HPG
Identifiers
Aliases	PLG, plasminogen, plasmin, HAE4
External IDs	OMIM: 173350; MGI: 97620; HomoloGene: 55452; GeneCards: PLG; OMA:PLG - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	160,754,097 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	12,638,272 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; metanephric glomerulus; ; human kidney; ; Descending thoracic aorta; ; ascending aorta; ; testicle; ; tibial nerve; ; right coronary artery; ; gonad;
	Top expressed in
	left lobe of liver; ; gallbladder; ; human fetus; ; yolk sac; ; fetal liver hematopoietic progenitor cell; ; sexually immature organism; ; abdominal wall; ; primitive streak; ; embryo; ; thoracic diaphragm;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	apolipoprotein binding; protein domain specific binding; peptidase activity; protein binding; serine-type peptidase activity; signaling receptor binding; hydrolase activity; serine-type endopeptidase activity; chaperone binding; proteasome core complex binding; protein antigen binding; endopeptidase activity; enzyme binding; kinase binding;
Cellular component	blood microparticle; extracellular region; cell surface; extrinsic component of external side of plasma membrane; extracellular exosome; platelet alpha granule lumen; extracellular space; plasma membrane; extrinsic component of plasma membrane; intracellular membrane-bounded organelle; collagen-containing extracellular matrix;
Biological process	hemostasis; negative regulation of cell-substrate adhesion; negative regulation of fibrinolysis; negative regulation of cell-cell adhesion mediated by cadherin; platelet degranulation; extracellular matrix disassembly; positive regulation of fibrinolysis; tissue remodeling; negative regulation of cell population proliferation; blood coagulation; proteolysis; fibrinolysis; positive regulation of blood vessel endothelial cell migration; tissue regeneration; myoblast differentiation; muscle cell cellular homeostasis; proteolysis involved in cellular protein catabolic process; trophoblast giant cell differentiation; labyrinthine layer blood vessel development; mononuclear cell migration;
	Sources:Amigo / QuickGO
Orthologs
	5340
	18815
	ENSG00000122194
	ENSMUSG00000059481
	P00747
	P20918
	NM_001168338; NM_000301
	NM_008877
	NP_000292; NP_001161810
	NP_032903
	Wikidata
View/Edit Human	View/Edit Mouse

Plasmin is an important enzyme (EC 3.4.21.7) present in blood that degrades many blood plasma proteins, including fibrin clots. The degradation of fibrin is termed fibrinolysis. In humans, the plasmin protein (in the zymogen form of plasminogen) is encoded by the PLG gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122194 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059481 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: plasminogen".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122194 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059481 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: plasminogen".

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