Tissue factor

F3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AHW, 1BOY, 1DAN, 1FAK, 1J9C, 1JPS, 1O5D, 1TFH, 1UJ3, 1W0Y, 1W2K, 1WQV, 1WSS, 1WTG, 1WUN, 1WV7, 1Z6J, 2A2Q, 2AEI, 2AER, 2B7D, 2B8O, 2C4F, 2CEF, 2CEH, 2CEZ, 2CFJ, 2EC9, 2F9B, 2FIR, 2FLB, 2HFT, 2PUQ, 2ZP0, 2ZWL, 2ZZU, 3ELA, 3TH2, 3TH3, 3TH4, 4IBL, 4M7L, 4Z6A, 4ZMA, 4YLQ, 2FLR
Identifiers
Aliases	F3, CD142, TF, TFA, coagulation factor III, tissue factor
External IDs	OMIM: 134390; MGI: 88381; HomoloGene: 1511; GeneCards: F3; OMA:F3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	94,541,759 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	121,528,697 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; palpebral conjunctiva; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; amniotic fluid; ; stromal cell of endometrium; ; left uterine tube; ; lower lobe of lung; ; gallbladder; ; left ovary;
	Top expressed in
	Eustachian tube; ; corneal stroma; ; skin of external ear; ; cervix; ; tunica adventitia of aorta; ; respiratory epithelium; ; olfactory epithelium; ; esophagus; ; conjunctival fornix; ; deep cerebellar nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cytokine receptor activity; phospholipid binding; serine-type endopeptidase activity; protease binding;
Cellular component	membrane; extracellular matrix; intrinsic component of external side of plasma membrane; plasma membrane; extracellular region; extracellular exosome; cell surface; extracellular space; serine-type peptidase complex; integral component of membrane; collagen-containing extracellular matrix;
Biological process	hemostasis; positive regulation of protein kinase B signaling; positive regulation of endothelial cell proliferation; cytokine-mediated signaling pathway; positive regulation of cell migration; activation of blood coagulation via clotting cascade; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of angiogenesis; blood coagulation, extrinsic pathway; activation of plasma proteins involved in acute inflammatory response; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of positive chemotaxis; blood coagulation; protein processing;
	Sources:Amigo / QuickGO
Orthologs
	2152
	14066
	ENSG00000117525
	ENSMUSG00000028128
	P13726
	P20352
	NM_001993; NM_001178096
	NM_010171
	NP_001171567; NP_001984
	NP_034301
	Wikidata
View/Edit Human	View/Edit Mouse

Tissue factor, also called platelet tissue factor or Coagulation factor III,^[5] is a protein present in subendothelial tissue and leukocytes which plays a major role in coagulation and, in humans, is encoded by F3 gene. Its role in the blood clotting is the initiation of thrombin formation from the zymogen prothrombin. Thromboplastin defines the cascade that leads to the activation of factor X—the tissue factor pathway. In doing so, it has replaced the previously named extrinsic pathway in order to eliminate ambiguity.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117525 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028128 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhou RF, Liu Y, Wang YX, Mo W, Yu M (October 2011). "Coagulation factor III (tissue factor) is required for vascularization in zebrafish embryos". Genetics and Molecular Research. 10 (4): 4147–4157. doi:10.4238/2011.October.31.2. PMID 22057990.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117525 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028128 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Zhou RF, Liu Y, Wang YX, Mo W, Yu M (October 2011). "Coagulation factor III (tissue factor) is required for vascularization in zebrafish embryos". Genetics and Molecular Research. 10 (4): 4147–4157. doi:10.4238/2011.October.31.2. PMID 22057990.

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