Factor X

F10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C5M, 1EZQ, 1F0R, 1F0S, 1FAX, 1FJS, 1G2L, 1G2M, 1HCG, 1IOE, 1IQE, 1IQF, 1IQG, 1IQH, 1IQI, 1IQJ, 1IQK, 1IQL, 1IQM, 1IQN, 1KSN, 1LPG, 1LPK, 1LPZ, 1LQD, 1MQ5, 1MQ6, 1NFU, 1NFW, 1NFX, 1NFY, 1P0S, 1V3X, 1WU1, 1XKA, 1XKB, 1Z6E, 2BMG, 2BOH, 2BOK, 2BQ6, 2BQ7, 2BQW, 2CJI, 2D1J, 2EI6, 2EI7, 2EI8, 2FZZ, 2G00, 2GD4, 2H9E, 2J2U, 2J34, 2J38, 2J4I, 2J94, 2J95, 2JKH, 2P16, 2P3F, 2P3T, 2P3U, 2P93, 2P94, 2P95, 2PHB, 2PR3, 2Q1J, 2RA0, 2UWL, 2UWO, 2UWP, 2VH0, 2VH6, 2VVC, 2VVU, 2VVV, 2VWL, 2VWM, 2VWN, 2VWO, 2W26, 2W3I, 2W3K, 2WYG, 2WYJ, 2XBV, 2XBW, 2XBX, 2XBY, 2XC0, 2XC4, 2XC5, 2Y5F, 2Y5G, 2Y5H, 2Y7X, 2Y7Z, 2Y80, 2Y81, 2Y82, 3CEN, 3CS7, 3ENS, 3FFG, 3HPT, 3IIT, 3K9X, 3KL6, 3Q3K, 3SW2, 3TK5, 3TK6, 4A7I, 3KQB, 3KQC, 3KQD, 3KQE, 3LIW, 3M36, 3M37, 4BTI, 4BTT, 4BTU, 4Y6D, 4Y71, 4Y76, 4Y79, 4Y7A, 4Y7B, 4ZHA, 4ZH8, 5K0H
Identifiers
Aliases	F10, FX, FXA, coagulation factor X
External IDs	OMIM: 613872; MGI: 103107; HomoloGene: 30976; GeneCards: F10; OMA:F10 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	113,149,529 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	13,106,676 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; stromal cell of endometrium; ; right auricle of heart; ; canal of the cervix; ; ectocervix; ; gastric mucosa; ; right ovary; ; left ovary; ; right coronary artery; ; left uterine tube;
	Top expressed in
	left lobe of liver; ; yolk sac; ; gallbladder; ; embryo; ; fetal liver hematopoietic progenitor cell; ; epithelium of small intestine; ; blood; ; sexually immature organism; ; granulocyte; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; phospholipid binding; hydrolase activity;
Cellular component	endoplasmic reticulum lumen; intrinsic component of external side of plasma membrane; plasma membrane; extracellular region; Golgi lumen; extracellular space;
Biological process	hemostasis; positive regulation of protein kinase B signaling; positive regulation of cell migration; blood coagulation; proteolysis; endoplasmic reticulum to Golgi vesicle-mediated transport; blood coagulation, extrinsic pathway;
	Sources:Amigo / QuickGO
Orthologs
	2159
	14058
	ENSG00000126218
	ENSMUSG00000031444
	P00742
	O88947
	NM_000504; NM_001312674; NM_001312675
	NM_001242368; NM_007972
	NP_000495; NP_001299603; NP_001299604
	NP_001229297; NP_031998
	Wikidata
View/Edit Human	View/Edit Mouse

Coagulation factor X (EC 3.4.21.6), or Stuart factor, is an enzyme of the coagulation cascade, encoded in humans by F10 gene.^[5] It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for its synthesis.

Factor X is activated, by hydrolysis, into factor Xa by both factor IX with its cofactor, factor VIII in a complex known as intrinsic pathway; and factor VII with its cofactor, tissue factor in a complex known as extrinsic pathway.^[6] It is therefore the first member of the final common pathway or thrombin pathway.

It acts by cleaving prothrombin in two places (an Arg-Thr and then an Arg-Ile bond), which yields the active thrombin. This process is optimized when factor Xa is complexed with activated co-factor V in the prothrombinase complex.

Factor Xa is inactivated by protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa is increased 1000-fold by the presence of protein Z, while it does not require protein Z for inactivation of factor XI. Defects in protein Z lead to increased factor Xa activity and a propensity for thrombosis. The half life of factor X is 40–45 hours.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126218 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031444 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "F10 gene: MedlinePlus Genetics". medlineplus.gov.
^ Camire RM (August 2021). "Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics". Journal of Thrombosis and Thrombolysis. 52 (2): 383–390. doi:10.1007/s11239-021-02456-w. PMC 8531165. PMID 33886037.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126218 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031444 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Medline2024-5] "F10 gene: MedlinePlus Genetics". medlineplus.gov.

[Camire-6] Camire RM (August 2021). "Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics". Journal of Thrombosis and Thrombolysis. 52 (2): 383–390. doi:10.1007/s11239-021-02456-w. PMC 8531165. PMID 33886037.

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