| ENAM |
|---|
|
| Identifiers |
|---|
| Aliases | ENAM, AIH2, AI1C, ADAI, enamelin |
|---|
| External IDs | OMIM: 606585; MGI: 1333772; HomoloGene: 9698; GeneCards: ENAM; OMA:ENAM - orthologs |
|---|
|
| Gene location (Mouse) |
|---|
| | Chr. | Chromosome 5 (mouse)[2] |
|---|
| | Band | 5|5 E1 | Start | 88,635,834 bp[2] |
|---|
| End | 88,653,908 bp[2] |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - testicle
- islet of Langerhans
- vastus lateralis muscle
- striated muscle tissue
- biceps brachii
- Skeletal muscle tissue of biceps brachii
- human kidney
- deltoid muscle
- corpus epididymis
- buccal mucosa cell
|
| | Top expressed in | - molar
- tracheobronchial tree
- intestinal villus
- Ileal epithelium
- perirhinal cortex
- choroid plexus of fourth ventricle
- CA3 field
- lactiferous gland
- inferior colliculi
- superior colliculus
|
| | More reference expression data |
|
|---|
| BioGPS | |
|---|
|
| Gene ontology |
|---|
| Molecular function | | | Cellular component | | | Biological process | | | Sources:Amigo / QuickGO |
|
|
| Wikidata |
|
Enamelin is an enamel matrix protein (EMPs), that in humans is encoded by the ENAM gene.[5][6] It is part of the non-amelogenins, which comprise 10% of the total enamel matrix proteins.[7] It is one of the key proteins thought to be involved in amelogenesis (enamel development). The formation of enamel's intricate architecture is thought to be rigorously controlled in ameloblasts through interactions of various organic matrix protein molecules that include: enamelin, amelogenin, ameloblastin, tuftelin, dentine sialophosphoprotein, and a variety of enzymes. Enamelin is the largest protein (~168kDa) in the enamel matrix of developing teeth and is the least abundant (encompasses approximately 1-5%) of total enamel matrix proteins.[6] It is present predominantly at the growing enamel surface.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000132464 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029286 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mårdh CK, Bäckman B, Holmgren G, Hu JC, Simmer JP, Forsman-Semb K (May 2002). "A nonsense mutation in the enamelin gene causes local hypoplastic autosomal dominant amelogenesis imperfecta (AIH2)". Human Molecular Genetics. 11 (9): 1069–74. doi:10.1093/hmg/11.9.1069. PMID 11978766.
- ^ a b "Entrez Gene: ENAM enamelin".
- ^ Nanci A, Ten Cate AR (2012). Ten Cate's Oral Histology (8th ed.). Elsevier India. ISBN 978-8131233436. OCLC 1027350695.