| IL20 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | IL20, IL-20, IL10D, ZCYTO10, Interleukin 20 |
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| External IDs | OMIM: 605619; MGI: 1890473; HomoloGene: 10286; GeneCards: IL20; OMA:IL20 - orthologs |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 1 (mouse)[2] |
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| | Band | 1|1 E4 | Start | 130,834,722 bp[2] |
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| End | 130,839,188 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - gonad
- pancreatic ductal cell
- seminal vesicula
- smooth muscle tissue
- stromal cell of endometrium
- olfactory zone of nasal mucosa
- left uterine tube
- skin of abdomen
- myometrium
- skin of limb
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| | Top expressed in | - zygote
- secondary oocyte
- primary oocyte
- right ventricle
- artery
- mammillary body
- ventral tegmental area
- skin of abdomen
- carotid body
- major salivary gland
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | | | Cellular component | | | Biological process | | | Sources:Amigo / QuickGO |
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| Wikidata |
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Interleukin 20 (IL20) is a protein that is in humans encoded by the IL20 gene which is located in close proximity to the IL-10 gene on the 1q32 chromosome.[5][6] IL-20 is a part of an IL-20 subfamily which is a part of a larger IL-10 family.[5]
IL-20 subfamily also includes other cytokines, including IL-19, IL-20, IL-22, IL-24, and IL-26.[5] Members of the cytokine IL-20 subfamily form an important link between the immune system and epithelial tissues because receptors for these cytokines are highly expressed on epithelial cells and are almost exclusively produced by cells of the immune system.[7]
IL-20 requires an IL-β-subunit receptor (IL-20RB) for signaling, which can form a functional heterodimeric receptor with either the α-subunit of the IL-20 receptor (IL-20RA) or the α1-subunit of the IL-22 receptor (IL-22RA1). Both of these receptor variants allow efficient IL-20 signaling.[5] Receptors for IL-20 are expressed in the skin, lungs, ovary, testes, and placenta.[5] IL-20 is mainly produced by myeloid cells such as monocytes, granulocytes, and dendritic cells but can also be produced by keratinocytes and fibroblasts.[5] The expression of IL-20 is stimulated by IL-1β, IL-17, IL-22, TNF, and LPS.[5] The main cellular targets of IL-20 are keratinocytes, endothelial cells, and adipocytes.[8] IL-20 has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes.[9]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000162891 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026416 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c d e f g Rutz S, Wang X, Ouyang W (December 2014). "The IL-20 subfamily of cytokines--from host defence to tissue homeostasis". Nature Reviews. Immunology. 14 (12): 783–795. doi:10.1038/nri3766. PMID 25421700. S2CID 29114703.
- ^ Kontogiorgis CA, Hadjipavlou-Litina DJ (January 2002). "Non steroidal anti-inflammatory and anti-allergy agents". Current Medicinal Chemistry. 9 (1): 89–98. doi:10.2174/187152306778017683. PMID 11860351.
- ^ Ouyang W, Rutz S, Crellin NK, Valdez PA, Hymowitz SG (2011-04-23). "Regulation and functions of the IL-10 family of cytokines in inflammation and disease". Annual Review of Immunology. 29 (1): 71–109. doi:10.1146/annurev-immunol-031210-101312. PMID 21166540.
- ^ Sa SM, Valdez PA, Wu J, Jung K, Zhong F, Hall L, et al. (February 2007). "The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis". Journal of Immunology. 178 (4): 2229–2240. doi:10.4049/jimmunol.178.4.2229. PMID 17277128. S2CID 1870754.
- ^ "Entrez Gene: Interleukin 20".